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Showing posts with label genetic manipulation. Show all posts
Showing posts with label genetic manipulation. Show all posts

Thursday, April 18, 2013

World's first GMO Babies Born



Or were they? 

by Rebecca Taylor | London, England | LifeNews.com | 7/2/12 12:30 PM
Many people are talking about Michael Hanlon’s piece in the Daily Mail about the first genetically modified babies being born. 

A couple of readers have e-mailed this article to me (Rebecca) so I went to the journal of Human Reproduction looking for the latest issue and found nothing from Jacques Cohen. I then found that Dr. Cohen is the Laboratory Director at ART Institute of Washington at Walter Reed National Military Medical Center. Apparently he left Institute for Reproductive Medicine and Science of St Barnabas and works for a U.S. military hospital. (A fact that I find very disturbing.)
I scratched my head for a minute and dug deeper and think I have found the original paper. It was from 2001, not 2012. 
The technique is called “cytoplasmic transfer.” I did not start blogging until 2005, so I had no idea that this genetic engineering of embryos took place. I then found an in depth report in the Washington Monthly on the issue. Sharon Brownlee explains how the technique raised concerns at the Food and Drug Administration (FDA) and it seems they put a stop to cytoplasmic transfer in the United States:
In the mid-1990s, embryologist Jacques Cohen pioneered a promising new technique for helping infertile women have children. His technique, known as cytoplasmic transfer, was intended to “rescue” the eggs of infertile women who had undergone repeated, unsuccessful attempts at in vitro fertilization, or IVF. It involved injecting the cytoplasm found inside the eggs of a fertile donor, into the patient’s eggs.
When the first baby conceived through cytoplasmic transfer was born in 1997, the press instantly hailed Cohen’s technique as yet another technological miracle. But four years later, the real story has proven somewhat more complicated. Last year, Cohen and his colleagues at the Institute for Reproductive Medicine and Science of St. Barnabas, a New Jersey fertility clinic, set off alarm bells among bioethicists with the publication of a paper detailing the genetic condition of two the 17 cytoplasmic-transfer babies born through the clinic to date. The embryologists reported that they had endowed the children with extra bits of a special type of genetic material, known as mitochondrial DNA, or mtDNA, which came with the cytoplasm transferred from the donor eggs to the patient’s.
Just how normal those children will turn out to be is anybody’s guess. At a recent meeting in Europe, the New Jersey researchers reported that one of the children conceived through cytoplasmic transfer has been diagnosed with “pervasive developmental disorder,” a catch-all term for symptoms that range from mild delays in speech to autism. Cohen’s group maintained that it is extremely unlikely that cytoplasmic transfer and the resulting mishmash of mtDNA is to blame.
But geneticists have only begun to trace the connections between mtDNA and a host of diseases ranging from strange metabolic ailments to diabetes and Lou Gehrig’s disease, and some experts argued that the child’s disorder may well be caused by a mismatch between the donor and mother’s mtDNA. As Jim Cummins, a molecular biologist at Murdoch University in Western Australia, put it: “To deliberately create individuals with multiple mitochondrial genotypes without knowing the consequences is really a step into the dark.”
Since 1998, the Food and Drug Administration (FDA) has argued that genetically manipulated embryos are a “biological product,” and therefore subject to regulation, just like medical devices and drugs. But because of a quirk in federal law, the FDA’s authority in this sphere is far from certain.


But in a recent UK DailyMail publishing:
"The disclosure that 30 healthy babies were born after a series of experiments in the United States provoked another furious debate about ethics.

So far, two of the babies have been tested and have been found to contain genes from three 'parents'.
sciencetubes 235x147 Genetically Modified Babies Created in US   The Worlds First
Fifteen of the children were born in the past three years as a result of one experimental programme at the Institute for Reproductive Medicine and Science of St Barnabas in New Jersey.

John Smeaton, national director of the Society for the Protection of Unborn Children, said: 'One has tremendous sympathy for couples who suffer infertility problems. But this seems to be a further illustration of the fact that the whole process of in vitro fertilisation as a means of conceiving babies leads to babies being regarded as objects on a production line.

'It is a further and very worrying step down the wrong road for humanity.' Professor Cohen and his colleagues diagnosed that the women were infertile because they had defects in tiny structures in their egg cells, called mitochondria.

They took eggs from donors and, using a fine needle, sucked some of the internal material - containing 'healthy' mitochondria - and injected it into eggs from the women wanting to conceive.

Because mitochondria contain genes, the babies resulting from the treatment have inherited DNA from both women. These genes can now be passed down the germline along the maternal line.

A spokesman for the Human Fertilisation and Embryology Authority (HFEA), which regulates 'assisted reproduction' technology in Britain, said that it would not license the technique here (UK) because it involved altering the germline."


Read more: http://www.dailymail.co.uk/news/article-43767/Worlds-GM-babies-born.html#ixzz2QqqqFIHO
Follow us: @MailOnline on Twitter | DailyMail on Facebook



http://naturalsociety.com/worlds-first-genetically-modified-babies-created-in-us/

http://www.lifenews.com/2012/07/02/worlds-first-genetically-modified-babies-born-or-were-they/


More of Rebecca's article
"...or were they?"


I want to discuss it because everything is not exactly how it seems.
Hanlon’s undated piece discusses a technique IVF doctors have used to “rejuvenate” an infertile woman’s eggs by injecting the cytoplasm of another woman’s healthy egg. Factors inside the cytoplasm help the infertile woman’s egg in fertilization. When doctors injected the cytoplasm of the healthy egg, it contained mitochondria from the donor egg. Those mitochondria have DNA from the woman who donated that egg. So the after that hybrid egg is fertilized, the resulting embryo has the DNA from 1 man, and 2 women. A genetic modification that any girl would pass onto her offspring since mitochondria are inherited from the mother only. The Daily Mail article reads:
The world’s first genetically modified humans have been created, it was revealed last night.
The disclosure that 30 healthy babies were born after a series of experiments in the United States provoked another furious debate about ethics.
So far, two of the babies have been tested and have been found to contain genes from three ‘parents’.
Fifteen of the children were born in the past three years as a result of one experimental programme at the Institute for Reproductive Medicine and Science of St Barnabas in New Jersey.
Full article:  
http://www.lifenews.com/2012/07/02/worlds-first-genetically-modified-babies-born-or-were-they/





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Friday, February 04, 2011

First IVF babies born using new chromosome counting technique




Engineered Humans


February 4th, 2011 in Medicine & Health / Research

     
The first babies have now been born in the UK using a new technique pioneered at Oxford University to select the best embryos for IVF.
The advance could bring hope to many British couples struggling to have a child and going through many cycles of  treatment.
George and Helen Ashton from Gloucestershire are thought to be the first couple to have babies in the UK after using a technique called microarray CGH with IVF embryos five days after fertilization.
The technique allows the embryos to be checked for the right number of chromosomes before implantation in an IVF treatment, lessening the chance of miscarriage or Down's syndrome.
The Ashtons had twins last November following treatment at the Oxford Fertility Unit, an independent IVF clinic which maintains strong research partnerships with the University. The boys, Alex and Louis, are now 11 weeks old.
The strategy of applying microarray CGH, or comparative genomic hybridisation, to five-day-old embryos, or 'blastocysts', was developed by Dr. Dagan Wells and Dr. Elpida Fragouli at the University of Oxford, with funding from the Oxford Biomedical Research Centre and in collaboration with partners in the health services and industry.
"If a sperm and egg come together and produce an embryo with the wrong number of chromosomes, the embryo will usually fail to establish a pregnancy or miscarry," explains Dr. Dagan Wells of the Nuffield Department of Obstetrics and Gynaecology.
As with routine IVF treatment, several eggs are produced and fertilized. Five days later at the blastocyst stage, a small number of cells are removed from the growing embryo and microarray CGH is used to check for any significant abnormalities present in the chromosomes. In effect it scans the DNA packed up in the cells' chromosomes for any clear problems. Results are available 24 hours later.

Based on this information, it is possible to make sure that only embryos with the correct number of chromosomes are transferred in IVF, improving pregnancy rates as a result.
The Ashtons had first tried IVF in 2004 and had had five unsuccessful IVF cycles. They were told that it was probably down to bad luck and poor embryo selection, so the couple went to the Oxford Fertility Unit and had their embryos tested using microarray CGH.
"We were of the opinion that this was going to be our last go," Mr Ashton said. "Array CGH has been a godsend to us – but the big issue is that not many people know about it."
There have been other couples who have given birth to babies after receiving this treatment in Oxford, and a couple from Lancashire had a baby shortly after Christmas after opting for a closely related technique at a Manchester clinic.
Tim Child, director of the Oxford Fertility Unit and a senior fellow at the Nuffield Department of Obstetrics and Gynaecology at Oxford University, said: 'We are proud that Oxford Fertility Unit was the first clinic in the UK to use blastocyst chromosome screening successfully. We have a number of couples who have already given birth to babies using this method and we look forward to helping many more.'
An ongoing study by Dr. Wells and colleagues, part of which was published in the journal Fertility and Sterility last year, has revealed that pregnancy rates after chromosome testing were increased by more than 50% in a group of 200 American patients undergoing IVF treatment. Other studies by the Oxford University group have shown microarray CGH has an accuracy of greater than 95% for detecting abnormal embryos.
Dr. Wells says: "For IVF treatment there are two problems. Firstly, many of the embryos produced in a typical IVF cycle have the wrong number of chromosomes or significant chunks of DNA missing or duplicated. Secondly, the usual assessments done in an IVF clinic, which involve looking at embryos under the microscope to see how they are growing, cannot distinguish embryos with lethal chromosome problems from those that are healthy.
"The method we have developed allows us to identify which embryos have the correct number of chromosomes. These  should have the best chance of producing a baby and the lowest chances of miscarrying or having Down's syndrome.'


Assessing the Risk of Genetic Damage

Dr. Wells does caution that a randomized clinical trial is necessary to be able to say exactly how much benefit microarray CGH provides in reducing the risk of miscarriage and Down syndrome and in improving IVF success rates, and further clinical studies are needed to reveal which patients will benefit the most. There is evidence, however, that couples who have experienced several miscarriages may benefit from this type of testing.
The technique is available now – a company Reprogenetics now provides the test to multiple IVF clinics in the UK – but adds an extra £2,000 on top of the cost of an IVF cycle. The hope is that new innovations being developed at the University of Oxford will lower prices further in the near future.
"In the long run, this could actually save the NHS money,' says Dr. Wells, "as well as reduce the emotional and physical stresses suffered by couples who often have to undergo multiple cycles of IVF treatment in order to have a child."


Monster Baby
Stephen Kennedy, head of the Nuffield Department of Obstetrics and Gynaecology at Oxford University and clinical director of women's services at the Oxford Radcliffe Hospitals NHS Trust, says: 'This is a perfect example of how patients are benefitting from the unique collaborative partnership between the University, Oxford Fertility Unit and the Oxford Biomedical Research Center in translational research, without which it would be difficult to introduce new scientific advances into clinical practice.'
Provided by Oxford University
"First IVF babies born using new chromosome counting technique." February 4th, 2011. http://www.physorg.com/news/2011-02-ivf-babies-born-chromosome-technique.html


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